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Free Radical Biology & Medicine has created a new series of podcasts featuring commentary and discussion of recently published Special Issues and/or Invited Review articles in the journal. In each podcast, an invited moderator and an author/guest editor discuss state-of-the-art research in the field of redox biology. Free Radical Biology & Medicine Special Issues and Invited Reviews are well cited and provide valuable insights for basic scientists and clinicians with special interest in redox signaling and pathophysiology. Our podcasts also aim to provide a useful platform for undergraduate/postgraduate teaching and research, as they capture current developments in redox biology and importantly offer career advice to Early Career Researchers.
Episodes
Tuesday May 16, 2023
Tuesday May 16, 2023
Discussing the FRBM issue 'Hidden Networks of Aberrant Protein Transnitrosylation Contribute to Synapse Loss in Alzheimer's Disease' written by Stuart A. Lipton.
Speaker: Prof. Stuart A. Lipton, Scripps Research, UC San Diego, Yale School of Medicine, USA
Moderator: Prof. D. Allan Butterfield, University of Kentucky, USA
Prof. Stuart Lipton is a Professor and the Founding Director of the Neurodegeneration New Medicine Center, the Stepp Family Foundation Endowed Chair in the Department of Molecular Medicine of the Scripps Research Institute. Dr. Lipton is also an Adjunct Professor at the University of California, San Diego School of Medicine and an Adjunct Professor of the Yale University School of Medicine in the Department of Neurology. Dr. Lipton is a pioneer in the field of drug development and application for neurodegenerative disorders. He developed, characterized, and patented the first NMDA-type glutamate receptor to fight moderate to severe Alzheimer's Disease.
- [0:41] Introduction of Dr. Lipton
- [6:25] Dr. Lipton's training and career thus far
- [9:30] How Dr. Lipton has managed his large research group, numerous grants, and seeing neurological patients, all while extensively traveling for lectures and collaborations
- [12:15] Similarities and differences between S-nitrosylation and protein O-phosphorylation
- [23:13] What causes synapses to be lost in the transnitrosylation process & how the new agent, nitrosynapsin, would overcome these processes
- [40:40] Major factors in the triad of enzymes & why UCHL-1 is the first of these three enzymes to undergo S-nitrosylation
- [51:50] Relative contribution of the transnitrosylation mechanism to synaptic loss in light of other mechanisms
- [58:00] Final comments on Dr. Lipton's exciting research
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