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Free Radical Biology & Medicine has created a new series of podcasts featuring commentary and discussion of recently published Special Issues and/or Invited Review articles in the journal. In each podcast, an invited moderator and an author/guest editor discuss state-of-the-art research in the field of redox biology. Free Radical Biology & Medicine Special Issues and Invited Reviews are well cited and provide valuable insights for basic scientists and clinicians with special interest in redox signaling and pathophysiology. Our podcasts also aim to provide a useful platform for undergraduate/postgraduate teaching and research, as they capture current developments in redox biology and importantly offer career advice to Early Career Researchers.
Episodes
Thursday Jun 22, 2023
Thursday Jun 22, 2023
Discussing the FRBM issue 'Lipid Peroxidation in Alzheimer's Disease' written by D. Allan Butterfield.
Speaker: Prof. D. Allan Butterfield, University of Kentucky, USA
Moderator: Prof. Jose Vina, Universidad de Valencia, Spain
Prof. D. Allan Butterfield is the Alumni Association Endowed Professor of Biological Chemistry; Associate Vice President for Research for Centers and Institutes and for RPAs; Director of the Redox Metabolism Shared Resource Facility; Interim Executive Director of Tracy Farmer Institute for Sustainability and the Environment; and Research Professor at the University of Kentucky.
- [0:25] Introduction of Dr. Butterfield
- [4:00] How Dr. Butterfield's maintained his early career
- [12:30] The source of peroxides in the neuronal membranes
- [16:13] The relevance of lipid oxidation in brain activity
- [24:30] How Dr. Butterfield's work in redox proteomics helps us to understand the role of specific proteins in the development of Alzheimer's pathology
- [37:03] Why metabolic disorders have such a major risk factor for the development of dementia
- [42:30] How down syndrome is a model of Alzheimer's
- [47:50] Dr. Butterfield's thoughts on future antioxidant strategies in the prevention and treatment of Alzheimer's & new therapeutic approaches
- [55:00] Advice for young people pursuing science and medicine as a career
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