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Free Radical Biology & Medicine has created a new series of podcasts featuring commentary and discussion of recently published Special Issues and/or Invited Review articles in the journal. In each podcast, an invited moderator and an author/guest editor discuss state-of-the-art research in the field of redox biology. Free Radical Biology & Medicine Special Issues and Invited Reviews are well cited and provide valuable insights for basic scientists and clinicians with special interest in redox signaling and pathophysiology. Our podcasts also aim to provide a useful platform for undergraduate/postgraduate teaching and research, as they capture current developments in redox biology and importantly offer career advice to Early Career Researchers.
Episodes
Saturday Jul 29, 2023
Saturday Jul 29, 2023
Discussing the FRBM issue 'Bench to bedside transition for pharmacological regulation of NRF2 in non-communicable diseases' published in the January 2023 issue of the journal.
Speaker: Prof. Masayuki Yamamoto, Tohoku Medical Megabank Organization, Japan
Moderator: Prof. Giovanni Mann, King's College London, UK
Prof. Masayuki Yamamoto is the Professor Director of Tohoku University Medical Megabank, an integrated biobank with two prospective large population cohorts for exploring personalized healthcare and medicine.
He has received numerous international awards such as the Lester Packer Award (2018) from SFRRI, Research Excellence Award from the Federation of Asia and Oceania Biochemists and Molecular Biologists (2021), Kahoku Bunka Association Prize (2021), and Ando-Momofuku Research Excellence Prize (2023).
- [0:29] Introduction of Dr. Yamamoto
- [5:07] Dr. Yamamoto's early career and important collaborations
- [15:49] Collaborating with mentor James Douglas Engle
- [27:07] Projects in a little black notebook
- [31:28] If cellular molecular studies due to phase 2 enzymes or involved in antioxidant enzymes
- [49:15] Similar key NRF2 architecture in human organs and mice
- [54:35] Does intervention of the key 1 NRF2 system contribute in any way to personal healthcare and medicine?
- [56:20] How to treat the brain independent of the heart and adjusting medicine interventions internationally.
- [59:41] A search for an activator or inhibitor of NRF2 pathways
- [1:08:13] Conclusion
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